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Antioxidant Deters Exercise-Related Fatigue

Posted on March 17, 2016, 6 a.m. in Exercise Dietary Supplementation Mitochondria

As a dietary supplement, glutathione may boost mitochondria levels in muscle.

An antioxidant compound itself, glutathione also recycle others antioxidants such as vitamins C and E.   Wataru Aoi, from Kyoto Prefectural University  (Japan), and colleagues employed a mouse model to assess the effects of glutathione supplementation on muscle, finding that the compound prevented pH level decreases otherwise associated with exercise.  In addition, sedentary animals fed glutathione experience significant increases in mitochondrial DNA levels and a marker of mitochondria in skeletal muscle (PGC-1alpha) as well.  In their study involving 8 healthy men, assigned to undergo exercise tests with or without glutathione supplementation (1 gm/day for 2 weeks).  Those men who received glutathione displayed lower lactate levels and decreased fatigue measures, as compared to the non-supplemented subjects. The study authors submit that: “glutathione supplementation improved lipid metabolism and acidification in skeletal muscles during exercise, leading to less muscle fatigue.”

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Wataru Aoi, Yumi Ogaya, Maki Takami, Toru Konishi, Yusuke Sauchi, Eun Park, et al.  “Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism.”  Journal of the International Society of Sports Nutrition 2015, 12:7, 6 February 2015.

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